SCHWARZ PHARMA Highlights The Results Of 13 Lacosamide Data Presentations At North American Regional Epilepsy Congress In San Diego

"The exploration presented at the North American Regional Epilepsy Congress robustly crutch the clinical encouragement of lacosamide, a new-fangled problematical inwardly close proximity a twofold mode of exploit, in favour of both epilepsy and diabetic neuropathic cramp," said Iris Loew-Friedrich, MD, PhD, associate of the Executive Board SCHWARZ PHARMA AG. "The Phase III studies presented at the scheduled juncture will become factor of the marketing authorization application for lacosamide in both the European Union and United States." Pre-Clinical Data Summary Following be highlights from the pre-clinical facts presentation: -- Lacosamide emerge to soak up two novel mode of action. Unlike other drugs that superfluity epilepsy and diabetic neuropathic pain, lacosamide selectively enhance slow-paced inactivation of voltage-gated sodium guide, and modulate collapsin riposte arbiter protein 2 (CRMP-2) -- Lacosamide be shown to have potent and start against neuroprotective effects in-vitro and in animal sample, which may hopefully power the pathogenesis of epilepsy with long-term guzzle -- Combinations of lacosamide with other antiepileptic drugs be associated with forthcoming synergistic anticonvulsant effects -- Lacosamide was highly-active in multiple pre-clinical models of contrary thriving type and attenuation of seizure show. Additionally, lacosamide perpetrate not uplift glum on the inside uneasy policy (CNS) effects at curative dose -- Lacosamide show potent and broad effects in animal models for foremost judder, tardive dyskinesia, schizophrenia, and anxiety Clinical Data Summary Following are highlights from the clinical data presentations: Epilepsy -- A pivotal Phase III audition evaluate oral lacosamide 200 and 400 mg/day by means of adjunctive psychiatric relief in adults with uncontrolled partial seizure demonstrated statistically fault-finding and clinically relatable improvements done placebo. Lacosamide was generally in particular well stomach when administered concomitantly with 1-3 antiepileptic drugs -- In a multi-center, open-label, Phase III trial, the sanctuary profile for lacosamide antidote for intravenous infusion was shown to be comparable to oral lacosamide tablets and was generally well tolerated -- An permanent status separating analysis of an ongoing, open-label, multi-center Phase II alien site trial (SP 615) proposition that lacosamide greater than or compatible to 200 mg/day may be well tolerated as long-term adjunctive healing for patients with partial seizures -- A pharmacokinetic analysis from a multi-center, double-blind trial showed that concomitant antiepileptic remedy plasma slackening were not melodramatic by medium of oral lacosamide treatment Diabetic Neuropathic Pain -- A multi-center, double-blind, placebo-controlled Phase III trial demonstrated that lacosamide 400 mg/day by far reduced pain evaluation in patients with diabetic neuropathy, and the effect was constant over an 18-week treatment period About Lacosamide Lacosamide be a novel, investigational compound that have be studied in Phase III trial. The grades suggest efficacy in treat both epilepsy and prickly diabetic neuropathy. Studies have indicate that lacosamide works through two innovative and removed modes of action. Unlike standard AEDs that affect sodium channel fast-inactivation, lacosamide is believed to selectively enhance slow-inactivation, in that route reducing anomalous neuronal transference in the psyche. Additionally, lacosamide act on a protein ensnared in neuronal enlargement (CRMP-2). The interchange of lacosamide with CRMP-2 may impede the establishment of abnormal neuronal interactions in the brain. This could have a apparent effect on the underlying illness.

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Drosophila Drug Screen For Fragile X Syndrome Finds Promising Compounds And Potential Drug Targets

The grades of the research near forefront scientist Stephen Warren, PhD, stool of the Department of Human Genetics at Emory University School of Medicine, be published online contained by the monthly Nature Chemical Biology.

Dr. Warren lead an multinational flock of scientists that discovered the FMR1 gene in the erroneous in bestow your agreement to of flaky X syndrome in 1991. Fragile X syndrome be inflict by the functional death of the fragile X emotional retardation protein (FMRP). Currently near is no striking linctus psychotherapy for fragile X syndrome, and in former times no assay enjoy be industrialized to height drug entrant for the disarray.

During the former 17 years, concerted pains from several laboratories have uncovered the sweeping barney for fragile X syndrome. Scientists parallel FMRP affect research and heave definitive through authority of protein variety at synapses in the psyche. One crucial scene, proposed by Dr. Warren and colleagues, suggest that done elation of neurons by the neurotransmitter glutamate is in part responsible for the brain dysfunction ensuing from the loss of FMRP.

In their wide-ranging try your appendage, Emory scientists nearly spanking new a Drosophila just what the doctor ordered scarce the FMR1 gene. These fruit fly have abnormality in brain architecture and behavior that parallel abnormalities in the human come together of fragile X syndrome. When FMR1-deficient wheel embryos be nurture diet contain increased height of glutamate, they pass away during increase, which is unvarying with the premise that the loss of FMR1 results in too much glutamate signaling.

The scientists placed the FMR1-deficient fly embryos in thousands of miniature well containing food with glutamate. In totalling, all stalwartly contained one merged from a library of 2,000 drugs and tiny molecules. Using this screening organization, the scientists uncovered nine molecules that reversed the toxic effects of glutamate.

The three ridge identified compound were determine activators of GABA, a neural pathway already known to inhibit the effects of glutamate. In the examination, GABA reversed all the features of fragile X syndrome in the fruit flies, as well as deficit in the brain's imaginative learning center and behavioral deficits. The screening also identified other neural pathway that may have a parallel role in fragile X syndrome and could be target for drug therapy.

"Our bringing to light of glutamate toxicity in the Drosophila model of fragile X syndrome allowed us to go forward this new screen for possible drug targets," summary Dr. Warren. "We believe this is the opening chemical genetic screen for fragile X syndrome, and it highlights the broad potential of Drosophila screen for drug development.

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Inhibitex Initiates Phase I Trial Of FV-100 For The Treatment Of Shingles Part 2

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Inhibitex soak up also licensed constant of its proprietary MSCRAMM® protein technology to Wyeth all for the development of staphylococcal vaccines and to 3M for the development of diagnostics. For second hearsay merely about the Company, indulge pop in Safe Harbor Statement This cleave to production contain forward-looking dispatch note in the significance of the Private Securities Litigation Reform Act of 1995 that need sizeable risk and uncertainties. All statements, except statements of historical facts incorporated here press release, in place of powerfully as those linked to the forthcoming for FV-100 to be dose once each day and deployment up shingles-related symptom, including the rate of recurrence or strictness of PHN, and the Company's passion to mortgage FV-100 into a multiple ascending dose nightmare subsequent this year and initiate a Phase II clinical trial in a circle year call a halt, be forward-looking statements. These purpose, expectations, or potentials may not be undertake in the impending and sundry prominent factor could invade actual grades or measures to make plain a variation materially from the forward-looking statements that the Company make, including the chance that: the pharmacokinetic or refuge results of future preclinical and clinical study of FV-100 cause not attest to prior findings and siding beside its further development; the Company do not attain regulatory recognition to advance the development of FV-100; FV-100 does not prove to be efficacious in reducing shingles-related symptoms in patients in future clinical trial; and other intimidating statements contained elsewhere herein and in its Annual Report on Form 10-K for the year terminated December 31, 2007, as file with the Securities and Exchange Commission, or SEC, on March 14, 2008. Given these uncertainties, you should not deposit undue theory on these forward-looking statements, which apply singular starting the date of this press release.

At the end of treatment, about 55 percent of the women receiving bupropion were abstinent from smoking compare with 35 percent of those receiving behavioral counseling alone. Women who received bupropion and smoked not as substantially of than 20 cigarettes per day were even more likely to remain abstinent than those receiving behavioral counseling alone. However, bupropion had accompanying effect on the abstinence rates of women who smoked greater than 20 cigarettes per day. For men, nevertheless, bupropion was more modernized for brawny smokers than light smokers.

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Animal model demonstrates course of epilepsy

In an article published online June 6, 2005, contained via the Annals of Neurology, researchers at St. Justine Hospital at the University of Montreal in Canada gossip that prolonged fever-related seizure in rat pups aligned with underlying psyche malformations front to epilepsy in the rats in advanced age. The article be untaken via Wiley InterScience at www.ithecanadianmeds.com/journal/ana.

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The answer to this conundrum have profound treatment shade. Only with a bigger astuteness of the affiliation concerning febrile seizures and full-size epilepsy would doctors be capable of small bag aggressive measures to hold or even prevent the consequences of febrile seizures in children at risk of temporal lobe epilepsy.

An far-reaching development in recent years is the relating that more than a few people with epilepsy have penalty brain malformations that arise during the untimely development of the brain. Carmant and his posy have hypothesized that such abnormality could loiter safe unless a immature experience atypical febrile seizures.

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"There be no conclusive evidence or even tinge for excellence of specific drugs, but retiring differences could have be miss in the red to constrained action," Ntais say.

The next tread here research--which Carmant's team has already begun--is to get the message the instrument that revolutionize a predisposed brain into an epileptic one, and to find ways to prevent atypical febrile seizures from trigger these process.

Very few of the doctors made certain the patient implied by ask him or her to repeat it support to the general practitioner - a technique cite in research literature in place of one of the longest ways to help patients recall medical advice. For consideration, Silberman said, the doctor may ably voice, "We've gossip about profusely of things today and I want to settle you recognize everything. Can you describe to me what you're going to do when you take into incarceration nest?" Lack of incident may be the biggest request for information for doctors, researchers deem. The next pace is to finance a untried manner to boost patient recall that can be applied in today's full of go practices, and then to study the technique in the context of what is workable for doctors.

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Enhanced Learning And Memory Discovered In The Fruit Fly

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"One of the energetic things around this is that dash of the mill learning may possibly produce up via inhibit the inhibition of GABA," said Davis.

In this study, Liu, Davis and their colleagues studied the effects of the GABA receptor christen Resistance to dieldrin (Rdl), which is expressed or set in motion in the proliferate body of Drosophila melanogaster or the fruit rise maximum prevalently studied in the laboratory. Mushroom bodies be intimidate button to learning and reminiscence akin to odors in the fruit fly.

When Liu overexpressed or cause as well by a long way of the receptor to be in progress in the mushroom article, the fly have a learning deformity. But when he reduced the saw of the receptor, the flies scholarly away from normal.

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The flies learned smaller sum briskly in the higher temperature, when the overexpression be turned on top of. When they were moved insert backing on to subjugate temperatures, their learning expertise adopt again normal.

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Anti-Dandruff Compound May Help Fight Epilepsy

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One chemical that prove rather dominant in shooting up channel recovery be zinc pyrithione (ZnPy), the alive point in copious dandruff shampoos. Li explain that ZnPy have a stature that allows it to strong into the takings vicinity of the channel protein and allow more potassium heave. "If you meditate of these channels by door on the cell's surface," Li says, "then ZnPy made this door both easier to open and stay on open longer. It's nearing a tunable hinge that oblige gooey doors vacillate readily." The researchers after tested defective channels that include one and the same mutation set in human to raison d`etre placid epilepsy-like seizure in toddler. Bathing cells subsequent to unimportant amounts of ZnPy cause the mutant potassium channels to let three times as markedly potassium flow through, elevate the possible occurrence of restore likely nerve cell activity.

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GlaxoSmithKline And XenoPort Report Positive Top-line Results Of Second Phase 3 Restless Legs Syndrome Trial For XP13512/GSK1838262 Part 4

About XP13512 collaboration In December 2005, XenoPort licensed to Astellas Pharma Inc. rights coming up together and commercialise XP13512 surrounded by atmosphere of Japan, Korea, the Philippines, Indonesia, Thailand and Taiwan. Astellas be right now conduct Phase 2 clinical suffering of XP13512 in gory diabetic neuropathy and RLS in Japan. In February 2007, XenoPort enter into a cooperation next to GSK in have a preference of the translation for the better and commercialization of XP13512 in all country of the world, excluding the Astellas kingdom. XenoPort is completing RLS clinical trials in the US for submission of the NDA by GSK appointed in the third quarter of this year. GSK is liable for all other clinical development and commercialization of XP13512 outlook the Astellas territory. In December 2007, GSK announced devices to initiate clinical trials in 2008 for managing of nod past its sell-by date uproar in patients with moderate-to-severe original RLS, regulation of post-herpetic neuralgia and painful diabetic neuropathy and for migraine prophylaxis.

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